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Abf tracking5/16/2023 In infected individuals, G614 is associated with lower RT-PCR cycle thresholds, suggestive of higher upper respiratory tract viral loads, but not with increased disease severity. We found that the G614 variant grows to a higher titer as pseudotyped virions. The consistency of this pattern was highly statistically significant, suggesting that the G614 variant may have a fitness advantage. The shift occurred even in local epidemics where the original D614 form was well established prior to introduction of the G614 variant. Dynamic tracking of variant frequencies revealed a recurrent pattern of G614 increase at multiple geographic levels: national, regional, and municipal. Louis, MO 63130, USA.Ī SARS-CoV-2 variant carrying the Spike protein amino acid change D614G has become the most prevalent form in the global pandemic. ![]()
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